后COVID和疫苗接种综合征的认知障碍,抑郁和疲劳:一项大规模的横截面研究
Evelyne Hanc1, Katharina Koller2, Regina Herold2
1Department of Psychosomatic Medicine and Psychotherapy, University Hospital of Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054, Erlangen, Germany. evelyne.hanc@uk-erlangen.de.
European archives of psychiatry and clinical neuroscience
|November 19, 2025
概括
在COVID-19 (PASC) 和疫苗接种 (PVS) 后,认知障碍很常见,影响注意力和记忆力. 教育,年龄,抑郁和炎症等因素与PASC认知问题有关.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 传染性疾病 传染性疾病
背景情况:
- 持续的认知困难是COVID-19后的主要症状之一.
- 这项研究调查了COVID-19 (PASC) 后急性后续和疫苗接种后综合征 (PVS) 的认知障碍.
- 研究了认知功能障碍的风险因素和心理健康相关因素.
研究的目的:
- 在PASC和PVS中表征神经心理缺陷.
- 在PASC中识别与认知障碍相关的风险因素.
- 为了比较PASC和PVS患者之间的认知功能障碍模式.
主要方法:
- 进行了神经心理评估,包括注意力 (d2测试) 和口语流 (RWT).
- 测量了工作速度,记忆力 (数字间隔向后),抑郁,疲劳和CRP水平.
- 793名参与者 (723名PASC,70名PVS) 来自德国后COVID中心.
主要成果:
- 缺陷最常见的是工作速度 (61.7%),注意力 (54.7%) 和口语流 (48.8%).
- 在30.3%的参与者中观察到多领域功能障碍,64.5%的人有抑郁症状,92.4%的人报告疲劳.
- PVS患者表现出与PASC患者相似的认知模式,抑郁症状和疲劳水平.
- 在PASC中,低学历,年龄较大,抑郁症和CRP升高与认知障碍相关.
结论:
- 认知障碍在PASC和PVS中非常普遍.
- 心理和生物因素影响认知缺陷.
- 共享机制可能是PASC和PVS认知问题的基础,这需要进一步研究治疗策略.
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