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Updated: Jan 11, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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通过完整的化学合成实现的位置特定的ORF核酸盐-核糖酶修饰增强了mRNA稳定性和翻译性

Hiroto Iwai1, Yasuaki Kimura2, Masakazu Honma1

  • 1Research Unit, Research Division, Kyowa Kirin Co., Ltd., Tokyo, Japan.

Nature communications
|November 19, 2025
PubMed
概括

化学修饰增强了信使RNA (mRNA) 治疗方法. 一个关键的创新是2′-F修饰,提高了mRNA稳定性和翻译效率,以获得更好的治疗设计.

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