与SARS-CoV-2再感染相关的后急性后续症的多系统风险
Jue Tao Lim1,2, Liang En Wee3,4,5, Janice Yu Jin Tan6
1National Centre for Infectious Diseases, Singapore, Singapore. juetao.lim@ntu.edu.sg.
BMC global and public health
|November 19, 2025
概括
重新感染SARS-CoV-2显著增加了多个器官系统中急性后续病变的风险. 这些风险即使在接种疫苗和增强剂的个体中也存在,这凸显了需要重新感染预防策略的需要.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 再感染与急性后续病变的风险更高有关.
- 目前尚不清楚较轻微的Omicron变种再感染或高度接种疫苗的人群的再感染是否也会增加后急性风险.
研究的目的:
- 调查SARS-CoV-2再感染与发生后急性后果的风险之间的关联.
- 为了比较重新感染的个体,首次感染的个体和未感染的对照人群之间的急性后续病变的风险轨迹.
- 评估在接种疫苗和增强疫苗的人群中是否存在急性后续风险.
主要方法:
- 利用了来自新加坡的国家COVID-19数据库和医疗保健索赔数据 (2021年7月至2023年2月).
- 构建了SARS-CoV-2感染 (再感染和非再感染) 和未感染个体的队列.
- 在心血管,神经精神,内分泌,自身免疫,脏,呼吸道和胃肠道领域,比较300天新诊断的发病率和过重负担.
主要成果:
- 重新感染SARS-CoV-2与21%增加任何后急性后续症状的风险相关 (HR=1.21).
- 观察到心血管,胃肠道,神经,内分泌,呼吸和等疾病的风险增加.
- 与第一次感染相比,再感染的风险更大,并且在接种疫苗和增强疫苗的个体中持续存在.
结论:
- 重新感染SARS-CoV-2是发展后急性连续症的重要危险因素.
- 预防再感染的策略,包括更新的疫苗,提高了对感染的疗效,对于减少急性后并发症的负担至关重要.
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