相关实验视频

Updated: Jan 11, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

探索ASPN作为泛癌生物标志物,重点关注胃癌

Yue Feng^1,2,3,4, Sijiang Zhou^1,2,3,4, Bing Yang^1,2,3,4

¹Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

Discover oncology

|November 19, 2025

概括

升高的ASPN蛋白表达与较差的癌症预后相关. 在胃癌细胞中抑制ASPN抑制了扩散和入侵,这表明ASPN是潜在的治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

癌症是全球主要的健康威胁.
尚不完全了解ASPN蛋白在癌症中的作用.
调查ASPN的机制和监管是至关重要的.

研究的目的:

探索ASPN表达和各种癌症的预后意义.
分析ASPN与免疫透,TMB,MSI和药物敏感性的关联.
确定ASPN在胃腺癌 (STAD) 进展中的功能作用.

主要方法:

对多种癌症类型的表达分析和预后相关性.
KEGG和GO的丰富分析提供了功能性见解.
在体外测试 (RT-qPCR,WB,CCK-8,Transwell) 来评估ASPN对STAD细胞行为的影响.

主要成果:

高ASPN表达与几种癌症的预后不佳有关.
ASPN与免疫细胞透,TMB和MSI相关.
抗击ASPN降低了STAD细胞的活力,迁移,入侵和诱导的亡.

结论:

升高的ASPN是癌症的不良预后指标.
ASPN显示出作为生物标志物和治疗点的潜力,特别是在胃癌中.

关键词:

在 ASPN ASPN 中.胰腺癌是一种癌症.预测预测预测预测一个城市的城市.

更多相关视频

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...