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外周免疫细胞表型的变化及其在自闭症中的作用:从临床和动物模型研究的见解

Baowen Dong^1,2,3, Mengmeng Chang^2,3, Junchen Liu¹

¹Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.

Molecular psychiatry

|November 19, 2025

概括

本综述探讨了免疫系统功能障碍如何导致自闭症谱系障碍 (ASD). 研究强调了ASD中免疫细胞的改变,这表明了潜在的免疫调节治疗方法.

科学领域:

神经免疫学神经免疫学
发育神经科学的发展神经科学.

背景情况:

自闭症谱系障碍 (ASD) 是一种复杂的神经发育障碍,其致病源不明.
遗传和环境因素有助于ASD病因.
免疫神经发育轴是理解ASD的一个新兴框架.

研究的目的:

审查有关ASD外围免疫细胞子集变化的证据.
探索涉及ASD中淋巴细胞表型的致病机制.
支持开发针对ASD的免疫调节疗法.

主要方法:

临床队列研究的整合.
对动物模型的发现进行分析.
对免疫学和表型学数据的审查.

主要成果:

在ASD中主要的外周免疫细胞子集中观察到的功能性表型变化.
有证据表明,免疫失调有助于ASD的进展.
周围淋巴细胞表型与致病级联有关.

结论:

免疫系统功能障碍与ASD的发病有关.
了解免疫变化为新的治疗策略提供了目标.
免疫调节疗法在治疗自闭症方面表现有前途.

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相关概念视频

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.