量化早期生长逆境对晚年健康的影响
Raphael Goldman-Pham1, Matthew P Alter1, Rebecca Bao1
1Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Communications medicine
|November 19, 2025
概括
通过身高-GaP测量早期生长逆境,预测晚年死亡率. 这种精确指数可以识别健康风险并改善终身健康公平.
科学领域:
- 遗传学 遗传学 是一个
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 早期生长逆境会影响成年人的健康.
- 准确地评估成年期这种逆境是具有挑战性的.
- 研究了身高-GaP指数 (达到的和基因型预测的成年人身高之间的差异).
研究的目的:
- 为了评估身高GAP与早期生长逆境之间的关联.
- 评估身高-GaP与晚年所有原因和心血管死亡率之间的联系.
主要方法:
- 利用了来自ALSPAC和UKBiobank的数据,在DMHDS和MESA中进行复制.
- 使用多基因身高得分计算身高GaP.
- 采用回归模型来分析关联,调整共变量.
主要成果:
- 诸如更低的妊娠年龄和贫困等不利因素与更大的身高-GaP赤字有关.
- 高度-GaP赤字预测增加了全因,动脉样硬化心血管疾病和冠心病死亡率.
- 在多个研究队列中,关联是一致的.
结论:
- 介绍了身高-GaP作为成年人早期生长逆境的精度指数.
- 这个指数可以帮助研究长寿的发育起源.
- 这些发现支持改善整个生命周期的健康平等.
相关概念视频
Nature and Nurture
22.1K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.1K
Longitudinal Research
13.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.0K
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K
Lifestyle Factors and Health
397
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
397
Longitudinal Studies
454
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
454
Introduction to Stress and Lifestyle
502
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
502


