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骨关节炎中的性别不平等:一个生物信息学视角

Zhenye Guo¹, Zhengquan Dong², Liyun Cheng²

¹Department of Orthopaedics, Second Hospital of Shanxi Medical University, No.382, Wuyi Road, Xinghualing District, Taiyuan, 030000, Shanxi, China.

Clinical rheumatology

|November 19, 2025

概括

这项研究揭示了关键的基因和途径,这些基因和途径有助于女性骨关节炎的更高患病率和严重程度. 研究结果提供了潜在的性别特异性诊断标志物和骨关节炎的治疗点.

科学领域:

基因组学就是基因组学.
分子生物学分子生物学
生物医学研究生物医学研究

背景情况:

骨关节炎 (OA) 的发病率和严重程度在女性中比男性更高.
了解这种性别差异的遗传基础对于有针对性的干预至关重要.

研究的目的:

确定关键的基因和分子途径,负责骨关节炎中观察到的性别差异.
发现OA潜在的性别特异性诊断标志物和治疗点.

主要方法:

对三个基因表达综合 (GEO) 微阵列数据集 (GSE12021,GSE55457,GSE55584) 的综合分析.
鉴定差异表达基因 (DEGs) 和丰富分析 (基因本体学,KEGG通路).
构建和分析蛋白质-蛋白质相互作用 (PPI) 网络以识别通过RT-qPCR验证的枢纽基因.

主要成果:

与对照人群相比,在女性OA患者中确定了90个DEG,在男性OA患者中确定了375个DEG.
在性别之间发现了24种常见的DEGs (15个是上调,9个是下调).
在女性 (9) 和男性 (5) 中确定了不同的枢纽基因组,对CTGF,CX3CR1,IL6和JUN等关键基因进行RT-qPCR验证.

结论:

已确定的性别特异性基因和途径与女性OA的更高发病率和严重程度有关.
这些发现突出了潜在的性别特定的诊断生物标志物和骨关节炎的治疗策略.
这项研究为开发基于性别的OA个性化治疗提供了基础.

关键词:

生物信息学分析生物标志物生物标志物不同表达的基因.性别的不平等是性别不平等.骨关节炎是一种骨关节炎.

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