慢性中耳炎与输液在患有腺体缩的儿童:发展诊断预测模型的发展
Yu Wu1, Yuan Jiang2, Yan-Xun Han1
1Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Biomolecules & biomedicine
|November 19, 2025
概括
这项研究确定了患有腺缩 (AH) 的儿童慢性中耳炎与输液 (COME) 的关键风险因素. 一个新的名图有助于预测COME风险,帮助早期诊断和干预,以改善儿童发育.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿科健康 儿科健康
- 医学诊断 医学诊断 医学诊断
背景情况:
- 慢性中耳炎与输液 (COME) 显著影响儿童的发育.
- 腺体缩 (AH) 是儿童常见的疾病,通常与 COME 相关.
- 准确的COME风险评估对于患有AH的儿童至关重要,以便及时进行干预.
研究的目的:
- 在患有腺体缩 (AH) 的儿童中确定 COME 的风险因素.
- 开发和验证临床预测这个人群中COME风险的nomogram.
- 提高诊断准确度,帮助临床决策.
主要方法:
- 对311名通过侧鼻喉放射诊断出AH的儿童进行了回顾性分析.
- 使用最小绝对收缩和选择操作员 (LASSO) 进行风险因素识别.
- 雇佣了Firth的惩罚性后勤回归和内部验证 (引导) 来构建和评估预测模型.
主要成果:
- 确定年轻年龄,维生素D3缺乏,AH程度和耳 tympanometry结果作为关键风险因素.
- 预测性名图实现了0.945的高C指数 (内部验证:0.934).
- 该模型在各种风险值中显示出良好的校准和临床实用性.
结论:
- 一个经过验证的纳米图,包括年龄,维生素D3水平,AH程度和 tympanometry,可以有效预测患有AH的儿童的 COME 风险.
- 这个工具可以帮助临床医生和家庭评估和管理COME风险.
- 早期识别和干预可以减轻COME对儿童发育的不良影响.
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