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Updated: Jan 11, 2026

MS2-Affinity Purification Coupled with RNA Sequencing in Gram-Positive Bacteria
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Published on: February 23, 2021

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另一方面,细菌RNA聚合酶-西格玛因子相互作用的抑制剂在体内对MRSA表现出有效性

Jiqing Ye1,2, Cheuk Hei Kan3, Jiang Liu1,4

  • 1Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR of China.

Journal of medicinal chemistry
|November 19, 2025
PubMed
概括

新的ditioether化合物通过向RNA聚合酶 (RNAP) 和其西格玛 (σ) 因子,有效地抑制细菌转录. 这些新型抗菌剂对抗性格拉姆阳性病原体表现出强烈活性,并在临床前模型中表现出有效性.

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