在炎症性肠道疾病中的内镜切除伪多体中出现的频率
Elena De Cristofaro1, Irene Marafini1,2, Martina Franchin1
1Gastroenterology Unit, Policlinico Universitario "Tor Vergata," Rome, Italy.
Journal of Crohn's & colitis
|November 19, 2025
概括
在炎症性肠道疾病 (IBD) 患者中,12%的伪多形病变中发生了失生症,这挑战了良性假设. 不同质的穴位模式和缺少预示着发育不良,需要仔细的内镜评估.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 内镜检查是指内镜检查.
背景情况:
- 在炎症性肠道疾病 (IBD) 中的伪多通常被视为良性愈合后果.
- 新出现的证据表明,伪多可能隐藏着发育不良或瘤病变.
研究的目的:
- 为了前性地评估IBD患者内镜切除的伪多聚类病变中的发育不良的频率.
- 在这些病变中识别出发育不良的预测因子.
主要方法:
- 在2023年6月至2025年3月期间,在IBD患者中进行伪多型病变的结肠镜切除.
- 对切除的病变进行组织学分析,以对其进行分类 (炎症性,发育不良,腺瘤,IBD相关的发育不良).
- 多变量逻辑回归用于确定失生症的预测因子.
主要成果:
- 12.1%的切除的伪多形病变表现为发育不良,包括常规腺瘤和IBD相关的发育不良.
- 不同质的穴位模式 (OR=4.50) 和没有的情况 (OR=0.093) 是发生性发育不良的独立预测因素.
- 在周围的粘膜中没有观察到发育不良.
结论:
- 在IBD患者中,伪多型病变具有显著的发育不良率 (12.1%),这与均良性概念相矛盾.
- 特定的内镜特征,如异质的穴位图案和缺少,可以帮助识别高风险病变.
- 这些发现强调了对IBD中伪多的细致内镜评估的需要,而不是例行切除.
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