AhR-Siglec-15轴通过TRPML1调节溶酶体Ca2+释放,用于通过TRPML1进行声波刺髓母细胞瘤生长

Zhenfeng Wang1, Shunshun Li2,3, Xu Sun1

  • 1Department of Immunology & State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS, ) & Peking Union Medical College, Beijing, 100005, China.

Protein & cell
|November 19, 2025
PubMed
概括

声波刺子子组髓母细胞瘤 (SHH-MB) 的增长是由酸结合性免疫球蛋白类受体15 (Siglec-15) 驱动的. 向基碳化合物受体 (AhR) -Siglec-15通路为这种侵袭性儿科脑瘤提供了一个有希望的治疗策略.

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