在弗雷明汉心脏研究中,成人生命过程中的体力活动和痴呆的风险
Francesca R Marino1, Chenglin Lyu1, Yuqing Li2
1Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
JAMA network open
|November 19, 2025
概括
在中年和晚年保持体力活动与痴呆症风险降低有关. 成年早期的体力活动没有显示出与痴呆症发展相似的保护性关联.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 身体活动因其对痴呆症的保护作用而得到认可.
- 然而,身体活动对痴呆风险影响最大的特定生命阶段仍然不清楚.
研究的目的:
- 调查成年早期,中年和晚年身体活动水平与患全因性痴呆症或阿尔茨海默病 (AD) 痴呆症的风险之间的关联.
- 确定成人生命过程中的关键时期,用于减轻痴呆风险的体育活动干预措施.
主要方法:
- 一项前性队列研究利用了来自弗雷明汉心脏研究后代队列的数据.
- 参与者的身体活动是自我报告,并在成年早期,中年和晚年被分为五分之一 (Q).
- 随访事件所有原因和AD痴呆症进行了几十年,使用专家共识标准.
主要成果:
- 中年和晚年更高的身体活动水平与所有原因痴呆症的风险明显降低有关 (Q4/Q5与Q1).
- 具体来说,中年和晚年身体活动最高的五分位数 (Q4和Q5) 显示出痴呆的风险降低.
- 在成年早期的身体活动和随后的痴呆风险之间没有发现显著的关联. 在阿尔茨海默病痴呆症中观察到类似的模式.
结论:
- 中年和晚年更高的体力活动,但不是成年早期,与所有原因和阿尔茨海默病痴呆症风险的相似降低有关.
- 这些发现强调了中年和晚年持续体育活动对于预防痴呆症的重要性.
- 旨在延迟或预防痴呆症的干预措施在这些关键的成人生活阶段进行时可能最有效.
相关概念视频
01:26Longitudinal Studies
709
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
709
01:26Stress Prevention and Stress Management Techniques IV
366
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
366