产前电可以通过大脑到脏的信号调节母胎免疫激活
Zhiqing Zhang1, Weipeng Lin2, Jinglan Yan3
1Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250300, China; South China Research Center for Acupuncture and Moxibustion, Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Acupuncture Research Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China.
孕产妇的免疫激活通过脏巨细胞引发炎症,影响怀孕和后代的神经发育. 产前电 (ES) 的干预恢复了免疫平衡,改善了结果.
科学领域:
- 神经免疫学 神经免疫学
- 生殖免疫学 生殖免疫学
背景情况:
- 孕产妇免疫激活 (MIA) 与不良妊娠结果和后代神经发育问题有关.
- 与MIA相关的并发症的机制和干预措施尚不清楚.
研究的目的:
- 阐明α7尼古丁性乙胆受体 (α7nAChR) 在MIA诱导的炎症中的作用.
- 为了研究大脑-轴在调节妊娠期神经免疫恒温.
- 评估产前电刺激 (ES) 作为MIA的干预措施.
主要方法:
- 研究了α7nAChR介导的脏巨细胞激活和下游炎症级联 (IL-6).
- 绘制了副腹腔核-阴道-α7nAChR-脏电路的地图.
- 评估了产前ES对免疫平衡和围产期/神经发育结果的影响.
主要成果:
- 在脏巨细胞中α7nAChR激活驱动IL-6炎症级联,破坏母胎免疫平衡.
- 这一连串导致流产,新生儿存活率下降和成人神经精神病缺陷.
- 副腹腔核-阴道-α7nAChR-脏电路调节妊娠期的神经免疫恒温.
- 产前ES调节了巨细胞激活和免疫平衡,改善了产前期的结果,并减轻了后代的神经发育障碍.
结论:
- 大脑 - 轴,由准室内核 - 阴道 - α7nAChR - 回路调节,对于妊娠期神经免疫恒温至关重要.
- 针对这一轴为MIA相关并发症提供了一个有前途的治疗策略.
- 产前ES是一种可行的非药物治疗方法,可以预防MIA相关的不良结果.
更多相关视频
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
相关概念视频
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Gut-Brain Axis
