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在HIV-1免疫疗法中针对pDC/IFN-I轴

Lishan Su1, James Ahodantin, Guangming Li

  • 1Division of Virology, Pathogenesis and Cancer, Institute of Human Virology, Department of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Current opinion in HIV and AIDS
|November 19, 2025
PubMed
概括

向血细胞树突细胞 (pDC) 和1型干扰素 (IFN-I) 可以减少HIV-1炎症和储存器. 抑制这种途径可以逆转与艾滋病毒相关的疾病,并提高抗艾滋病毒免疫力,与PD1免疫检查点抑制剂一起工作.

关键词:
艾滋病病毒-1的储存库.这是一种炎症炎症炎症炎症.干扰素-I 是一种干扰素.干扰素刺激的基因是干扰素刺激的基因.在pDCDC中,pDC是类似干细胞的CD8 T细胞.

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