分层双氧化物的生物界面行为:使用实验和计算模型进行分散性和毒性评估
Ayush Vikram Singh1,2, Abhishek Sharma3,4, M Suresh Kumar1,2
1Environmental Impact Assessment, Audit and Planning, CSIR-National Environmental Engineering Research Institute, Nagpur 440020, India.
Langmuir : the ACS journal of surfaces and colloids
|November 19, 2025
概括
-层双氧化物 (Mg-Al LDH) 纳米片在环境相关度下显示出稳定的分散和低细胞毒性. 这项研究支持它们在各种领域的安全应用.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 毒理学 毒理学 毒理学
背景情况:
- 层状双氧化物 (LDH) 纳米板是具有广泛应用的多功能纳米材料.
- 了解它们的生物和环境相互作用对于安全和可持续的使用至关重要.
- Mg-Al LDH纳米板需要对其生物界面行为进行彻底调查.
研究的目的:
- 为了合成和表征Mg-Al LDH纳米片.
- 评估Mg-Al LDH的分散性,环境稳定性和生物相互作用.
- 使用集成的实验和计算方法评估Mg-Al LDH纳米片的安全性.
主要方法:
- 合成和Mg-Al LDH纳米片的表征.
- 在各种生物和环境介质中进行分散性测试.
- 在HepG2和HL60细胞中进行细胞吸收,活力,ROS生成,DNA损伤,亡和线粒体透性测试.
- 计算对接研究与apoptotic信号蛋白.
主要成果:
- 在相关介质中,Mg-Al LDH纳米片在长达72小时的时间内表现出稳定的分散.
- 细胞吸收Mg和Al是剂量和时间依赖的;在高度 (mg/L) 中观察到细胞毒性.
- 在低度 (ng-μg/L) 时没有显著的ROS生成或DNA损伤;在高剂量时发生线粒体变化而没有诱导亡.
- 计算分析揭示了与亡蛋白质的弱相互作用.
- 环境相关度 (ng-μg/L) 对细胞参数没有显著的不良影响.
结论:
- -LDH纳米板显示了度依赖的生物安全性.
- 有利的分散特性和内在特征有助于具有低危险的生物特征.
- 这些发现支持Mg-Al LDH纳米板的安全应用,特别是在环境相关的度下.
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