用免疫炎症标记物跟踪过敏性鼻炎中的系统性炎症
Mustafa Ilker Inan1, Yasemin Akgul Balaban2, Fevzi Demirel2
1Department of Immunology and Allergy, Gulhane Training and Research Hospital, Ankara, Turkey, m.ilkerinan@gmail.com.
International archives of allergy and immunology
|November 19, 2025
概括
系统性炎症标志物如血小板与淋巴细胞比率 (PLR),系统性免疫炎症指数 (SII) 和泛免疫炎症值 (PIV) 在过敏性鼻炎 (AR) 中升高. 这些标记物,以及中性粒细胞与淋巴细胞比率 (NLR),随着鼻腔皮质类固醇治疗而改善.
科学领域:
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
- 生物标志物发现发现
背景情况:
- 过敏性鼻炎 (AR) 具有鼻炎的特征,但也涉及全身炎症反应.
- 评估系统性炎症生物标志物对于理解和管理AR至关重要.
研究的目的:
- 评估系统性炎症生物标志物在AR中的诊断和监测效用.
- 在AR患者中调查中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),系统性免疫炎症指数 (SII),泛免疫炎症值 (PIV) 和血清SCUBE水平.
主要方法:
- 这是一项前性研究,涉及88名AR患者和50名健康对照.
- AR患者接受了鼻腔皮质类固醇 (NCS) 治疗.
- 评估症状严重程度 (VAS,CARAT) 和测量NLR,PLR,SII,PIV和SCUBE水平治疗前后.
主要成果:
- 与对照组相比,AR患者的PLR,SII和PIV显著更高.
- 鼻腔皮质类固醇治疗导致显著的临床改善,并降低了NLR,PLR和SII水平.
- PIV,SII和PLR证明了它们作为AR的诊断生物标志物的潜力.
结论:
- 在AR中,PLR,SII和PIV升高,表明有显著的系统性炎症成分.
- 在有效的AR治疗下,NLR,PLR和SII水平下降.
- SII和PIV是有希望的,可访问的生物标志物,用于评估和监测过敏性鼻炎的炎症.
关键词:
过敏性鼻炎是一种过敏性鼻炎.炎症 炎症是一种炎症.鼻腔皮质类固醇是一种鼻腔皮质类固醇.中性粒细胞与淋巴细胞的比率.泛免疫性炎症的价值.血小板与淋巴细胞的比率.潜水艇 在潜水艇.系统性免疫炎症指数更多相关视频
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