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Updated: May 5, 2026

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激活PEG宿主以实现纳米载体的空间控制的表面功能化,用于生物医学应用

Mingchen Sun1, Wei Li1, Shaohua Zhang1

  • 1Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, Netherlands.

Science advances
|November 19, 2025
PubMed
概括

这项研究提出了一种新的方法,通过激活它们的惰性PEG冠状体,精确地功能化纳米载体. 这一突破改善了连接体的分布和稳定性,提高了纳米载体的有效性,用于先进的纳米医学应用.

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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