针对多发性骨髓瘤的起源,沿着造血干细胞淋巴细胞分化系的分化线路向多发性骨髓瘤

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Updated: Jan 11, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Jiaojiao Guo1,2, Yaru Li3, Zhiling Yan4

  • 1State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, National Clinical Research Center for Geriatric Disorders, FuRong Laboratory, Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China.

Science translational medicine
|November 19, 2025
PubMed
概括

多发性骨髓瘤从具有染色体1q放大特异性的B细胞开始,由FCRL5.5驱动. 针对这些细胞进行FCRL5 CAR T治疗对复发性或耐药性多发性髓瘤患者有希望.

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