预期的,随机的,受控的试验比较PROpofol与KetaMINE在急性病患者的快速顺序输管 (PROMINE):协议文件和统计分析计划
Raysa Cristina Schmidt1,2, Fernando Godinho Zampieri1, Fernando Jose da Silva Ramos1,2
1Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.
Critical care science
|November 19, 2025
概括
这项研究比较了胺和普罗波在重症患者的快速连续输管治疗中. 它旨在确定胺是否降低低血压,提供更安全的诱导剂替代品.
科学领域:
- 关键护理医学 关键护理医学
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在重症患者中,用于快速序列输管 (RSI) 的最佳催眠剂是不确定的.
- 普罗波是一种常见的诱导剂,在不稳定的患者中可能会加剧低血压的风险.
- 由于其更有利的血液动力学特征,胺可能提供更安全的替代品.
研究的目的:
- 评估胺作为一种更安全的替代品,以治疗严重病患者的RSI.
- 为了评估胺基与醇诱导期间低血压的发生率.
主要方法:
- 一项随机的,开放的,务实的,双中心研究,涉及170名重症患者.
- 患者被随机分配1:1接受基胺或普罗波用于内管道输入.
- 根据研究地点和血管压缩剂的使用进行分层,确保了平衡的组.
主要成果:
- 主要结果是诱导后10分钟内低血压的发生率.
- 二次结局包括死亡率,心肺骤停,严重的低血压/低血压,以及在1小时内试图输管.
- 数据收集的重点是血液动力学稳定性和患者安全.
结论:
- 该研究将为选择重症监护中的RSI催眠剂提供关键证据.
- 研究结果将澄清在重症患者中胺与醇的血液动力学影响.
- 结果可以告知和改善临床实践在重症监护病房内输管.
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