在儿科患者中与SARS-CoV-2感染相关的神经表现:系统性审查
Bruna de Jesus Santos1, Emerson André Negrão do Nascimento1, Ludmila Oliveira Dos Reis1
1Universidade Federal do Pará, Belém, PA, Brazil.
概括
发作,头痛和意识变化等神经症状在COVID-19的儿童和青少年中很常见. 这一系统性审查强调了儿童患者的这些关键发现.
科学领域:
- 神经学 神经学
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
背景情况:
- 在儿童群体中,SARS-CoV-2 (导致COVID-19的病毒) 的神经影响仍然是一个需要全面理解的领域.
- 现有的研究往往在年龄范围覆盖方面存在差距,需要对年龄在0至19岁的个体进行专注的审查.
研究的目的:
- 在0至19岁的患者中,系统地审查和识别与SARS-CoV-2感染相关的神经症状.
- 突出最常见的神经症状,并解决当前文献中特定年龄数据的局限性.
主要方法:
- 按照PRISMA (系统审查和元分析首选报告项目) 的指导方针进行了系统审查,并与PROSPERO (CRD42024520151) 注册.
- 搜索涵盖了2020年1月至2024年1月期间发表的观察和干预研究,利用PubMed/MEDLINE,Cochrane图书馆和VHL等主要数据库.
- 纳入标准集中在儿童和青少年确诊的SARS-CoV-2感染和神经症状.
主要成果:
- 最初的搜索产生了1283条记录,最终在严格的选和全文分析后选择了25项研究.
- 经常报告的神经症状包括发作,头痛,意识水平变化,嗅觉和味觉障碍,脑病和急性脑血管疾病.
结论:
- 神经学表现在儿科COVID-19病例中相对普遍,呈现从轻微症状到严重并发症的范围.
- 这些发现强调需要继续进行研究,以阐明儿童和青少年这些神经后续的潜在机制.
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