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左心室透支功能障碍增加了中期死亡的风险,在患有肝硬化的患者中
Sheng-Hao Li1, Lu Zhang1, Hong-Juan Li2
1School of Public Health, School of Public Health, Dali University, No. 2, Hongsheng Road, Dali Town, Dali Bai Autonomous Prefecture, Dali City 671000, Yunnan Province, P.R. China.
概括
左心室扩张功能障碍 (LVDD) 是一个独立的风险因素1年死亡率在患有肝硬化的患者. 早期发现LVDD可以帮助预测预后,特别是在没有肝脏恶性瘤的患者中.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 医学预测 医学预测
背景情况:
- 肝硬化是晚期肝病的常见并发症.
- 左心室扩张性功能障碍 (LVDD) 在肝硬化患者中越来越多地被认可.
- 对于LVDD在肝炎患者的预后影响,需要进一步阐明.
研究的目的:
- 调查左心室扩张性功能障碍 (LVDD) 与肝硬化的患者中期死亡率之间的关联.
- 确定LVDD作为该人群1年死亡率的独立风险因素.
- 为了将LVDD的预测值与既定的预后得分进行比较.
主要方法:
- 回顾性研究包括194名患有肝硬化的患者.
- 心声学用于将患者分类为LVDD和非LVDD组.
- 拉索,单变量和多变量考克斯回归分析用于风险因素识别.
- 卡普兰-梅尔曲线和时间依赖的ROC曲线用于生存分析.
主要成果:
- 左心室扩张功能障碍 (LVDD) 在47.4%的患者中被发现.
- LVDD是1年死亡率的独立预测因子 (危险比率=2.109,P=0.003).
- 在1年死亡率方面,LVDD的预测性能与CTP和MELD得分相似,特别是在没有肝癌的患者中.
结论:
- 左心室扩张性功能障碍 (LVDD) 显著增加了1年死亡的风险,患有肝硬化.
- LVDD作为一种有价值的预后标志物,特别是在没有肝脏恶性瘤的肝炎患者中.
- 定期对LVDD进行心声回声评估可能有助于风险分层和肝硬化的管理.
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