系统性炎症作为职业噪音暴露和抑郁风险之间的关联的调解者:基于人口的研究
JunCai Wang1,2,3, YuCheng Yuan4,3, WenHao Jiang1
1Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing 210009, Jiangsu, China.
Noise & health
|November 19, 2025
概括
职业噪音暴露增加了抑郁症的风险,长时间暴露与更高的几率有关. 系统性炎症部分调解了这种关联,这表明噪音通过炎症途径影响心理健康.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 神经免疫学 神经免疫学
- 公共卫生 公共卫生
背景情况:
- 职业噪音暴露是一个重要的环境压力因素.
- 噪音与心理健康,特别是抑郁症之间的联系需要进一步研究潜在的生物机制.
- 系统性炎症越来越被认为是各种慢性疾病的调解者,包括精神健康障碍.
研究的目的:
- 调查职业噪音暴露时间与抑郁风险之间的关联.
- 检查系统性炎症在职业噪音和抑郁症之间关系中的调解作用.
- 确定将工作场所噪音与抑郁症联系起来的生物学途径.
主要方法:
- 分析了来自17712名美国成年人的横截面数据 (国家健康和营养检查调查).
- 评估职业噪音暴露时间,抑郁风险 (患者健康问卷) 和全身炎症 (全身炎症反应指数 (SIRI)).
- 权重多变量后勤回归和调解分析 (bootstrapping) 来评估关联和SIRI的作用.
主要成果:
- 增加职业噪音暴露时间与更高的抑郁症风险相关 (每次暴露的顺序增加增加9.0%).
- 系统性炎症 (lnSIRI) 占职业噪音对抑郁症总影响的4.0%.
- 在所有灵敏度分析中,这种关联是强大的,根据各种混因素和炎症生物标志物进行调整.
结论:
- 职业噪音暴露是抑郁症的重要,可修改的风险因素.
- 系统性炎症起着调解作用,突出显示神经免疫路径.
- 解决声应激和炎症的工作场所干预措施可以降低抑郁风险.
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