墨西哥学龄前儿童的不良童年经历和神经内分泌生物标志物变化
I Martín-Estal1, D León Rojas1, J L Díaz-Gómez1
1Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, Monterrey, NL 64710, Mexico.
Psychoneuroendocrinology
|November 19, 2025
概括
儿童不良经历 (ACE) 与墨西哥儿童的压力激素变化有关. 父母滥用药物显著影响皮质醇水平,特别是在女孩身上,这表明需要量身定制的干预措施.
科学领域:
- 神经内分泌学神经内分泌学
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 在墨西哥,不良童年经历 (ACE) 很普遍,与成人健康问题有关.
- 儿童早期ACEs的生物标志物尚未得到充分了解.
- 早期的生活压力可能会影响发育中的神经内分泌系统.
研究的目的:
- 在3-5岁的墨西哥儿童中调查ACE和头发神经内分泌生物标志物 (皮质醇,皮质素,DHEA) 之间的关联.
- 分析社会人口因素 (年龄,性别,城市化) 对这些协会的影响.
- 探索潜在的值效应和特定的ACEs影响.
主要方法:
- 从ACESMEXICO队列中对237名儿童和226名照顾者的横截面研究.
- 178名儿童的头发样本分析了皮质醇,皮质素和DHEA.
- 儿科ACE和相关生命事件选器 (PEARLS) 用于ACE数据收集;应用线性回归模型.
主要成果:
- 患有两种ACE的儿童的皮质激素水平较高;≥3种ACE的儿童的皮质激素水平略有增加,这表明值效应.
- 父母滥用药物与更高的皮质醇水平有关,独立于ACE总量.
- 较高的DHEA水平与经济困难,农村生活,年轻年龄和男性性别有关.
结论:
- 在墨西哥学龄前儿童中,ACE与神经内分泌的改变有关.
- 农村和城市之间的差异以及父母的物质使用显著影响压力激素水平.
- 针对童年逆境的干预需要性别和环境敏感的方法.
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