PARPi和骨髓瘤;意大利MITO-MaNGO经验基于多中心调查的经验
M Turinetto1, C Marchetti2, G Scandurra3
1Gynecological Oncology Unit, Humanitas San Pio X, Milan, Italy; University of Turin, Oncology Department, Turin, Italy.
ESMO open
|November 19, 2025
概括
多 (ADP-ribose) 聚合酶抑制剂 (PARPi) 在卵巢癌患者中可能导致罕见的髓状瘤 (PrMN). 风险随着后期的治疗线增加,但PrMN在一线治疗中并不常见.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 泌尿生殖瘤学 泌尿生殖瘤学
背景情况:
- 多 (ADP-ribose) 聚合酶抑制剂 (PARPi) 越来越多地用于卵巢癌.
- 与PARPi相关的骨髓瘤 (PrMN) 越来越令人担忧,占与治疗相关的瘤的10-20%.
- 有限的数据存在PrMN风险与特定的PARPi,治疗线或以前的疗法.
研究的目的:
- 评估在临床试验之外接受治疗的卵巢癌患者中与PARPi相关的骨髓瘤 (PrMN) 的发生率.
- 根据特定的PARPi,治疗线和BRCA突变状态来分析PrMN发生率.
主要方法:
- 在17个意大利中心进行了一项调查,涉及在临床试验之外接受PARPi治疗的患者.
- 收集的数据包括患者人口统计数据,使用的PARPi,治疗线路和骨髓瘤瘤的发展.
主要成果:
- 在2320名患者中,56名 (2.55%) 患有PrMN (骨髓质疏松综合征或急性骨髓性白血病).
- 发病率因药物而异:olaparib 2.5%,niraparib 2%,rucaparib 3.4%. 这种药物的发病率有所不同. 风险在较晚的治疗线上显著增加 (12.2%在>第四线).
- PrMN的发生与治疗持续时间或BRCA突变状态没有明确的关联.
结论:
- PrMN是一种罕见但在卵巢癌中对PARPi具有临床意义的并发症.
- 当PARPi作为一线治疗时,PrMN特别不常见.
- 随着治疗暴露的增加,早期检测,监测和预测因素的识别对于管理PrMN至关重要.
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