暴露于新出现的污染物和妊娠糖尿病亚型的污染物:一个探索性的嵌套病例控制研究
Boya Wang1, Yiwen Qiu1, Nuo Xu1
1Department of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China; Department of Epidemiology & Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Journal of hazardous materials
|November 19, 2025
概括
暴露于包括紫外线稳定剂在内的新兴关注污染物 (CEC) 与妊娠糖尿病 (GDM) 有关. 这项研究发现,结合CEC暴露会增加GDM风险,特别是孤立的禁食高血糖症等亚型.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
背景情况:
- 孕期糖尿病 (GDM) 对母亲和婴儿的健康构成风险.
- 对新兴关注污染物 (CECs) 的联合暴露对GDM的影响在很大程度上是未知的.
- 紫外线稳定剂 (UVs) 是具有潜在内分泌干扰特性的CEC之一.
研究的目的:
- 调查99CEs和GDM在怀孕早期暴露之间的关联.
- 估计与CEC暴露相关的GDM亚型 (IFH,IPH,CH) 的风险.
- 为了确定GDM发展的关键 CEC贡献者.
主要方法:
- 一个嵌套的病例对照研究120名参与者 (90个GDM病例,30个对照) 来自周山队列.
- 对99个CEC的血度量化.
- 包括条件后勤回归,自适应弹性网 (AENET),贝叶斯内核机回归 (BKMR) 和量子式g计算 (qgcomp) 在内的统计分析被用来评估单次和组合暴露的影响.
主要成果:
- 在GDM病例中,包括UV-P在内的12个CEC的水平明显高于对照组.
- 在暴露于PAHs,PAEs,UVs和合成抗氧化剂与GDM风险之间观察到积极的关联.
- 联合CEC暴露与GDM,IFH和CH的风险增加正相关,qgcomp表明GDM,IFH和CH的显著关联.
- 据BKMR发现,UV-P和DEP是导致GDM风险的重要因素.
结论:
- 包括UV-P在内的CEC的联合暴露与妊娠糖尿病及其亚型的风险增加有关.
- 特定的化学品类如PAH,PAE,UV和合成抗氧化剂可能会导致GDM的发展.
- 需要在更大的前性研究中进行进一步的验证,并进行机制性调查,以证实这些发现.
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