长期的肥料应用促进土壤中持续的抗生素耐药性
Yi-Chun Wang1, Liang-Ying He1, Dai-Ling Wu2
1SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou, China.
Journal of hazardous materials
|November 19, 2025
概括
肥料应用显著增加了土壤抗生素度和耐药基因,即使在两年后. 这凸显了对土壤抗性的长期影响,以及需要更好的肥管理策略.
科学领域:
- 环境微生物学 环境微生物学
- 土壤科学 土壤科学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 肥料应用在农业中很常见,可能会影响土壤微生物群落和抗生素耐药性.
- 肥料对土壤抗生素耐药性的长期影响尚不清楚.
研究的目的:
- 调查猪和肥/堆肥在两年内对土壤抗生素度,抗生素耐药性基因 (ARG) 和移动遗传元素 (MGE) 的长期影响.
主要方法:
- 现场研究涉及肥料应用 (猪和肥/堆肥) 和对照场地.
- 在730天的土壤样本中量化抗生素度,ARG和MGE.
- 分析ARG位置 (等离子体相关的结合体) 和特定高风险基因的识别.
主要成果:
- 与对照组相比,经过改的土壤显示抗生素度 (4-300倍) 和ARG/MGE丰度显著更高,持续730天.
- 猪肥料处理过程中,抗生素含量特别高.
- 很大一部分 (62.5%) 的ARG在等离子体上被发现,如floR和aph3') -III等高风险基因持续存在.
- 较高的MGE水平表明持续的水平基因转移潜力.
结论:
- 肥料应用导致土壤中ARG和MGE的长期丰富,有助于持续的抗生素耐药性.
- 这些发现强调了改善肥管理实践的必要性,以减轻与抗生素耐药性相关的长期环境风险.
- 持续的水平基因转移潜力对抗生素耐药性的传播构成持续的风险.
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