在真核生物基因序列中对编码和非编码区域进行分类,采用使用混合Salp SwarmWhale算法设计的自适应性反口过器,并结合了修改后的错误函数.
Atanu Mondal1, Subhajit Kar1, Madhabi Ganguly2
1Dept. of Electronics, West Bengal State University, 126, Kolkata, India.
Computational biology and chemistry
|November 19, 2025
概括
这项研究引入了一种新的基因组信号处理技术,以准确识别基因序列中的编码和非编码区域. 该方法利用外子的周期-3特征,在预测蛋白质编码DNA片段方面达到高精度.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 信号处理 信号处理
背景情况:
- 在基因序列中的编码区域的准确分类对于理解蛋白质形成和生物功能至关重要.
- 鉴定编码区域是具有挑战性的,因为它们在真核生物基因组中的分布差异和低密度.
研究的目的:
- 提出一个数据独立和窗口长度独立的基因组信号处理技术,用于预测编码和非编码区域.
- 为了提高分类准确性,利用外子固有的周期-3特性.
主要方法:
- 使用混合Salp-Swarm-Whale优化算法设计了一个基于有限冲动响应的反隙过器 (ANF),以捕获周期-3频率.
- 基因序列使用Voss表示转换为二进制数据,并由ANF处理.
- 使用低通波和功率光谱密度估计来确定标记区域的第3期峰值.
主要成果:
- 提出的方法证明了序列长度的独立性,在短 (∼100 bp) 和长 (∼1,000,000 bp) 序列上都有效执行.
- 在基准序列 (F56F11.4a) 上的评估结果为AUC为0.98,准确度为0.954.
- 对来自各种生物体的191个序列的多样化数据集 (MOD191) 的测试导致AUC为0.91.
结论:
- 开发的基因组信号处理技术有效地识别了编码和非编码区域,通过利用异构体的第3期特征.
- 该方法在不同序列长度和多样化的生物体中的稳定性突出显示了其广泛基因组分析的潜力.
- 这种方法为生物信息学和基因组学研究中准确的基因序列分类提供了有希望的工具.
相关概念视频
Prokaryotic Gene Structure and Organization
1.8K
Prokaryotic genomes exhibit a streamlined organization of coding and non-coding regions essential for gene expression and protein synthesis. While coding regions contain the genetic instructions for proteins or functional RNAs, non-coding regions regulate the precise transcription and translation of these genes.Coding Regions: Proteins and RNAsThe primary coding regions, known as structural genes, include sequences transcribed into messenger RNA (mRNA) and ultimately translated into...
1.8K
Evolutionary Relationships through Genome Comparisons
6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
Gene Evolution - Fast or Slow?
7.9K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.9K
Organization of Genes
73.0K
Overview
73.0K
Cis-regulatory Sequences
11.5K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.5K
Cis-regulatory Sequences
4.0K
4.0K


