简要报告:大麻使用频率的变化是否与艾滋病毒感染者 (PWH) 饮酒和吸烟的变化有关 - 一个替代问题
Bridget M Whitney1, Joseph A C Delaney1, Lydia N Drumright2
1Department of Medicine, University of Washington, Seattle, WA, USA.
Drug and alcohol dependence
|November 19, 2025
概括
艾滋病毒感染者 (PWH) 增加的大麻使用与更多的酒精和香烟消费有关,这与大麻替代假设相矛盾. 然而,大麻使用量的减少与该人口中减少的酒精和烟草摄入量有关.
科学领域:
- 公共卫生 公共卫生
- 成 药物 药物 药物 药物
- 艾滋病毒研究 艾滋病毒研究
背景情况:
- 大麻替代假设表明,增加大麻使用可能会减少有害的酒精和烟草使用.
- 这种假设需要在艾滋病毒感染者 (PWH) 中进行评估,这是一个具有独特健康考虑因素的人群.
研究的目的:
- 评估PWH中的大麻替代假设.
- 确定加大大麻使用量是否与该队列中酒精或烟草使用量的减少相关.
主要方法:
- 分析了CNICS队列 (2009-2023) 中12143个PWH的纵向数据.
- 时间更新的线性混合模型和联合纵向/生存模型检查了大麻使用频率和随后的酒精/烟草消费的变化.
- 评估了两种大麻使用轨迹:增加使用和减少使用 (包括戒断).
主要成果:
- 增加大麻使用与每月饮酒日数增加0.67,每月重度饮酒日数增加0.25,危险饮酒的几率增加2.2倍.
- 增加大麻使用也与每天额外吸烟0.60支相相关.
- 相反,减少大麻使用与减少酒精和香烟消费有关.
结论:
- 与替代假设相反,PWH中大麻使用量增加与酒精和烟草使用量增加有关.
- 这些发现凸显了这种人群中大麻消费增加的潜在风险.
- 减少大麻使用证明了降低酒精和烟草摄入量的潜在好处.
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