围产中风后耐药性的预测因素
Miles Fisher1, Kristen Bolte1, Shilpa B Reddy1
1Division of Pediatric Neurology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
海马体积减少预测了患有围产性缺血性中风 (PIS) 的儿童的耐药性 (DRE). DRE在老年儿童中更为常见,手术可以改善控制.
科学领域:
- 儿科神经学 儿科神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 神经科学是一个神经科学.
背景情况:
- 围产期缺血性中风 (PIS) 是儿童神经缺陷的一个重要原因.
- 在患有PIS的儿童中确定耐药性 (DRE) 的预测因子对于及时干预至关重要.
研究的目的:
- 为了确定在有PIS史的儿童中DRE的预测因子.
- 评估PIS相关的儿童的神经结果和手术成功率.
主要方法:
- 对96名患有PIS的儿童进行了回顾性观察研究 (2012-2023年).
- DRE定义为对≥2种抗发作药物没有反应的发作.
- 分析包括神经成像,医疗记录和儿科中风结果测量 (PSOM).
主要成果:
- 56%的患有PIS的儿童患有;21%的儿童患有DRE.
- 海马体积减少是DRE的唯一预测因素 (OR 6.45,P=0.004).
- 65%的患有DRE的儿童接受了手术,62%的儿童获得了良好的发作结果.
结论:
- 海马体积减少是PIS后DRE的强有力的预测因素.
- 和DRE在患有PIS的老年儿童中更为普遍.
- 手术,包括半球切除和焦点切除,提供了有利的发作结果.
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