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Updated: Jan 11, 2026

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lysosome-targeting Chimeras: "流"蛋白质的设计,机制和降解

Muneeb Ur Rehman1, Xinxi Wu1, Qun Chen1

  • 1State Key Laboratory of Green and Efficient Development of Phosphorus Resources, Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1(st) Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei 430205, China.

Bioorganic chemistry
|November 19, 2025
PubMed
概括

Lysosome-targeting chimeras (LYTACs) 提供了一种新的方法来降解引起疾病的蛋白质,包括细胞外和膜结合的点. 这项技术扩大了向蛋白质降解的范围,超出了改善治疗方法的当前限制.

关键词:
降解器降解器降解器设计设计设计设计设计设计.细胞外蛋白质 细胞外蛋白质作用机制 作用机制膜结合的蛋白质 膜结合的蛋白质蛋白质的药用性 蛋白质的药用性有针对性的蛋白质降解降解.

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