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多发性硬化症中的抗肌肉性药物:系统性审查
Afra Darvishi1, Sina Pakkhesal2, Ali Alipour1
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
抗肌肉性药物 (AMs) 在多发性硬化症 (MS) 患者中有效治疗下泌尿道症状 (LUTS),改善生活质量. 然而,AM可能会导致认知缺陷,口腔干燥和头,需要在MS管理中仔细考虑.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 多发性硬化症 (MS) 是一种中枢神经系统免疫媒介疾病.
- 在MS患者中,下泌尿道症状 (LUTS) 很普遍.
- 抗肌肉类药物 (AMs) 是与MS相关的LUTS的第一线治疗.
研究的目的:
- 系统地审查抗肌肉类药物对多发性硬化症 (MS) 患者的影响.
- 评估AMs在管理MS相关的LUTS中的有效性和安全性.
主要方法:
- 系统审查遵循PRISMA和JBI的方法.
- 在PubMed,Scopus,Embase和Web of Science中进行全面的文献搜索.
- 包括15项研究,包括20-576名多发性硬化参与者 (平均年龄45-53岁,女性占主导地位).
主要成果:
- 补充剂显著改善了MS患者的尿路结果和生活质量.
- 在管理与LUTS相关的睡眠问题方面,AMs表现出有效性.
- 认知缺陷,口腔干燥 (xerostomia) 和头被确定为常见的副作用.
结论:
- 补充剂对MS相关的LUTS有效,提高生活质量和睡眠.
- 对AM的认知副作用需要谨慎,因为MS患者容易出现认知功能障碍.
- 谨慎监测和认知风险的考虑在为MS患者开处方AM时是必不可少的.
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