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肠道微生物群 - 脂肪交叉调节可溶性IL-6受体,影响运动反应在血糖控制和胰岛素敏感性

Yao Wang¹, Jiaming Wu², Jianyu Yao²

¹State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China.

Cell metabolism

|November 19, 2025

概括

运动反应有所不同,但脂肪细胞衍生的可溶性互白素-6受体 (sIL-6R) 是关键的. 准sIL-6R可以改善肥胖个体糖尿病预防的运动有效性.

科学领域:

代谢健康代谢健康
运动生理学运动生理学
内分泌学在内分泌学.

背景情况:

运动对于糖尿病管理至关重要,但个人的反应有很大差异.
了解运动反应变化背后的分子机制对于个性化干预至关重要.

研究的目的:

确定运动有效性改善代谢健康的关键分子调解剂.
阐明脂细胞衍生的可溶性互白素-6受体 (sIL-6R) 在运动反应中的作用.

主要方法:

在接受运动干预的肥胖个体中分析循环中的sIL-6R水平.
研究涉及肠道微生物组,白素,ADAM17,mTOR和HIF1α在脂肪细胞中的机制性途径.
在肥胖小鼠模型中进行脂肪细胞特异性ADAM17切除和便微生物群移植.

主要成果:

在运动反应者和不反应者之间,循环中的sIL-6R水平有所不同,与代谢改善相关.
在不响应患者中,肠道微生物组衍生的白含量升高,通过mTOR-HIF1α通路促进了ADAM17介导的sIL-6R产生.
通过IL-6转信号诱导的脂肪炎症,sIL-6R减弱了运动的益处.
在暴露于非响应性微生物群的小鼠中,脂肪细胞ADAM17的切除恢复了运动有效性.

结论:

来自脂肪细胞的sIL-6R是改善代谢健康的运动有效性的关键决定因素.
针对sIL-6R提供了一个有前途的策略,用于个性化糖尿病预防和管理.
调节肠道微生物群-脂肪细胞轴的干预措施可能会增强运动的益处.

关键词:

亚当17年亚当17年在IL-6信号传递过程中,IL-6 亚迪波基因 (Adipokine) 是一种可靠的药物.脂肪炎症是一种脂肪炎症.预防糖尿病预防糖尿病进行炼干预.炼皮肤运动皮肤肠-脂肪组织交叉的交叉链.胰岛素耐药性是一种胰岛素耐药性.氨酸 (leucine) 是一种蛋白质.

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