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纳米颗粒在受感染细胞中的选择性积累用于向药物输送
Amine Pochet1, Tom Bourguignon2, Axelle Grandé1
1Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France.
聚 ((乳糖-co-甘油酸) 纳米颗粒向受感染的肺细胞. 这些药物输送系统显示受感染的巨细胞的优先吸收,增强了对传染病的抗微生物疗效.
科学领域:
- 纳米医学是一种纳米医学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗微生物耐药性需要新的药物输送系统.
- 肺部感染需要有针对性的治疗来提高疗效和减少副作用.
- 基于纳米粒子的系统为局部药物输送提供了潜力.
研究的目的:
- 在结核病的小鼠模型中研究气溶液中聚乳糖合糖酸 (PLGA) 纳米颗粒的生物分布和细胞吸收.
- 为了确定感染细胞是否比未感染细胞更倾向于内化纳米颗粒.
主要方法:
- 在感染Mycobacterium tuberculosis的小鼠中注射PLGA纳米颗粒.
- 肺组织分析以评估纳米粒子生物分布.
- 流细胞计和显微镜测量膜巨细胞吸收纳米颗粒的数量.
主要成果:
- 在肺部广泛分布的PLGA纳米颗粒.
- 纳米颗粒优先积聚在膜巨细胞中,这是M.结核病的主要宿主细胞.
- 感染的巨细胞内化了比未感染的细胞更多的纳米颗粒.
- 这种偏好的吸收在细菌,病毒和寄生虫感染模型以及不同纳米材料的模型中观察到.
结论:
- 受感染的细胞表现出增强的纳米颗粒吸收,这是针对药物输送的关键特征.
- 这种选择性积累提供了一个强有力的策略,以改善抗微生物药物向受感染地点的输送.
- 基于纳米粒子的药物输送系统可以提高一系列传染病的治疗结果.
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