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相关概念视频

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

626
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
626
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection00:59

Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection

388
In pharmacokinetics, the elimination rate of a drug following a capacity-limited model is primarily controlled by two parameters: Vmax and KM. These parameters are crucial in how the drug behaves inside the body after administration.
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...
388
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

237
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
237
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

697
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
697
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

239
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
239

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相关实验视频

Updated: Jan 10, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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配方LAI:基于生理学的机器学习框架,用于加快长效注射配方的开发.

Ping Xiong1, Jinying Zhu1, Hao Zhong1

  • 1The State Key Laboratory of Mechanism and Quality of Chinese Medicine (MQCM), Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, 999078, China.

Journal of controlled release : official journal of the Controlled Release Society
|November 19, 2025
PubMed
概括

开发用于慢性疾病的长效注射剂 (LAI) 是缓慢的. 使用机器学习和建模的新计算框架加速了LAI设计,将开发时间从几年缩短到几个月.

关键词:
在现场形成凝.长效注射剂 长效注射剂机器学习 机器学习分子动力学分子动力学基于生理学的药物动力学建模.

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相关实验视频

Last Updated: Jan 10, 2026

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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科学领域:

  • 药物输送和配方科学 药物输送和配方科学
  • 计算机建模和模拟.
  • 药理动力学和药理动力学

背景情况:

  • 长效注射剂 (LAI) 为慢性疾病管理提供了潜力,但在发展时间,机制理解和体外-体内相关性方面面临挑战.
  • 目前的LAI开发严重依赖于漫长的试错过程,阻碍了有效的转化到临床实践.

研究的目的:

  • 开发和验证一个闭环计算框架,集成机器学习 (ML),生理学基础的药代动力学 (PBPK) 建模和分子动力学 (MD) 模拟,以加速LAI配方设计.
  • 证明该框架能够预测最佳的体外释放特征,并指导开发高效的LAI配方.

主要方法:

  • 整合ML,PBPK/PD建模和MD模拟以创建一个预测计算框架.
  • 使用Zilretta® (基于PLGA的注射剂) 作为PBPK/PD建模的基准,以定义目标体外释放配置文件.
  • 开发了一种基于ML预测的优化在位形成凝 (ISFG) 配方,用于氨酸的关节内输送.

主要成果:

  • 计算框架成功指导了优化ISFG配方的开发.
  • 开发的ISFG配方在老鼠的药理动力学研究中显示,与商业悬浮剂相比,药物暴露增加了34%.
  • MD模拟提供了对药物-聚合物相互作用的见解,这对于实现持续释放至关重要.

结论:

  • 拟议的计算框架将LAI临床前开发时间从5-7年大幅缩短到大约1-2年.
  • 这种预测性的"计算和验证"方法重新定义了LAI配方的开发,远离实证方法.
  • 该框架提供了一个可扩展的战略,用于合理和有效地开发长效注射配方.