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Updated: Jan 10, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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双核Cu2+-复合体破坏细胞通路并重新连接乳腺癌蛋白质组

Zeinab Ghasemishahrestani1, Simone Santiago Carvalho de Oliveira2, Rafaela Dos Santos Moraes Francisco3

  • 1Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Journal of proteomics
|November 19, 2025
PubMed
概括

两种新的铜 (II) 复合物R9和R10对乳腺癌细胞表现出强烈的抗瘤活性,表现优于西斯. 这些基于金属的药物诱导细胞亡,并表现出癌细胞选择性,提供了一个有前途的替代疗法.

关键词:
它具有抗癌活性.细胞灭亡 (apoptosis) 是一种死亡的过程.2+) - 复合体细胞毒性 细胞毒性蛋白质组学是指蛋白质组学.有反应性氧物种的反应性氧物种.

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