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Updated: Jan 10, 2026

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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在Rituximab参考药物和生物类似药物中的结构微异质性的多模态质谱表征

Youngseo Na1, Jill L Kinzer2, Luke Morrissette1

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church St, Ann Arbor, MI, 48109, USA.

International journal of biological macromolecules
|November 19, 2025
PubMed
概括

使用质谱学分析了三种rituximab生物类似药. 在生物类药物之间发现了最大的变异性,而不是与参考产品相比,这表明可以接受的现实世界结构变化.

关键词:
质谱测量质量谱测量后翻译修改 (PTMs) 是指翻译后的修改.里图西马布 (Rituximab) 是一种药物.

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