基尼胺激活NLRP3炎症酶途径,通过调节FXR/PERK/TXNIP途径来诱导毒性
Shenghui Cheng1, Baoyue Liu2, Zhinan Jin2
1Basic Medical College, Shanxi University of Chinese Medicine, Jinzhong, 030619, China.
Toxicon : official journal of the International Society on Toxinology
|November 19, 2025
概括
来自Fructus Gardeniae的Geniposide通过调低FXR和调高NLRP3/Caspase-1来引起损伤. 作为FXR激动剂的obeticholic 酸保护了这种基因胺诱导的毒性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 传统中国医药 传统中国医药
背景情况:
- 果实花园是一种传统的中医药和食物来源.
- 它的活性成分是Geniposide.
- 高剂量的基尼胺可能会导致脏毒性.
研究的目的:
- 调查基尼胺诱导的毒性.
- 探索潜在的分子机制.
主要方法:
- 基尼胺 (200,400毫克/公斤) 和基尼胺+肥酸 (OCA) 口服给SD大鼠1周.
- 生物化学分析 (血液尿素,肌,KIM-1,NGAL).
- 脏组织病理学. 脏病理学.
- 基因和蛋白质表达分析 (FXR,NLRP3,Caspase-1,PERK,TXNIP) 通过RT-qPCR和西方斑块.
主要成果:
- 热尼化物增加了血液尿素,肌,KIM-1,NGAL,并导致损伤.
- 基尼类降低调节的FXR和升高调节的NLRP3和Caspase-1.
- 治疗OCA缓解了基尼胺诱导的毒性,并使标志物水平正常化.
- 在OCA上调的FXR和下调的ER压力标志物 (PERK,TXNIP),NLRP3和Caspase-1).
结论:
- 基尼胺在老鼠中诱导毒性.
- FXR/PERK/TXNIP/NLRP3信号通路与基尼胺诱导的损伤有关.
- 准FXR通路可能提供一种保护策略,防止基尼胺毒性.
更多相关视频
07:38Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
8.8K
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
901
相关概念视频
01:24Nephrotic Syndrome I : Introduction
476
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
476
02:26NF-κB-dependent Signaling Pathway
9.7K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
9.7K
01:10Nephrons
6.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
6.3K