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静止状态ALFF和功能连接的变化与抑郁症中隐性和明确的自杀念头有关

Yelu Liu¹, Juan Deng², Jiaxin Zhou³

¹Department of Psychiatry, The Affiliated Hospital of Southwest Medical University, Luzhou, China; School of Clinical Medicine, Southwest Medical University, Luzhou, China; The Fourth People's Hospital of Chengdu, Chengdu, China.

Behavioural brain research

|November 19, 2025

概括

这项研究揭示了在大型抑郁症 (MDD) 中隐性和显式自杀念头 (SI) 的明显大脑网络差异. 这些发现凸显了抑郁症中两种类型的SI独特的神经生物学基础.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
脑部成像脑部成像

背景情况:

自杀念头 (SI) 是主要抑郁障碍 (MDD) 的关键症状.
了解隐式和显式SI的神经生物学基础对于开发有针对性的干预措施至关重要.
以前的研究还没有完全阐明不同形式的SI背后的独特神经机制.

研究的目的:

在患有重度抑郁症 (MDD) 的患者中,探索隐性和显式自杀念头 (SI) 之间的神经生物学差异.
识别特定的大脑区域和与隐式和显式SI相关的功能连接模式.
在MDD队列中调查隐式和显式SI措施之间的关系.

主要方法:

74名MDD患者和74名健康对照 (HCs) 接受了休息状态功能磁共振成像 (rs-fMRI).
隐性SI使用死亡/自杀隐性关联测试 (D/S-IAT) 进行评估,显性SI使用自杀意念贝克尺度 (BSSI).
分析了低频波动 (ALFF) 和基于种子的功能连接 (FC) 的幅度,以绘制神经活动和网络的地图.

主要成果:

患有MDD的患者表现出更高的隐性SI,这与显式SI得分有显著的相关性.
异常ALFF在隐性SI的右侧中后回形中发现,在显式SI的左侧岛屿,中后回形和右侧中回形 (MTG) 中发现.
观察到明显的FC模式:隐性SI的连接性增加,涉及右后中心,以及涉及左岛和右MTG的显式SI.

结论:

在MDD中隐性和明确的自杀念头与部分重叠但在很大程度上不同的神经基质有关.
自发大脑活动 (ALFF) 和功能连接 (FC) 的特定变化区分隐式和显式SI.
这些发现为SI的神经生物学提供了新的见解,可能为未来抑郁症治疗策略提供信息.

关键词:

低频波动的幅度低频波动的幅度功能连接性的功能连接性.大型抑郁症主要是抑郁症.静止状态功能磁共振成像技术自杀的想法自杀的想法

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