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Updated: Jan 10, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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P2Y12受体对手通过抑制DNA修复来降低B16黑色素瘤的辐射抵抗力.

Yuma Mizoguchi1, Natsuki Mori1, Kazuki Kitabatake1

  • 1Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.

Biological & pharmaceutical bulletin
|November 19, 2025
PubMed
概括

P2Y12受体对手可以通过抑制癌细胞DNA修复来增强放射治疗. 这种抑制DNA损伤反应 (DDR) 增加了癌细胞死亡,并改善了抗瘤效应,表明它们作为放射敏感剂的潜力.

关键词:
对DNA损伤的反应反应这是一个P2Y12受体.癌症 癌症 癌症 癌症 癌症辐射治疗疗法 辐射治疗疗法亚致命损害的恢复恢复.

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