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通过Arg1促进体对TME激活的CD47特异性CAR巨进行工程,以获得安全有效的固体瘤免疫疗法

Fuyu Du1,2, Meixi Jiang1,2, Jingjing Qiu3

  • 1School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, People's Republic of China.

Journal for immunotherapy of cancer
|November 19, 2025
PubMed
概括

化学抗原受体巨细胞 (CAR-Mφ) 疗法在固体瘤中表现有前途. 这项研究开发了一种对TME敏感的CAR-Mφ,向CD47,降低毒性并增强抗瘤效果,以获得更安全的癌症治疗.

关键词:
化学抗原受体 - - CAR免疫治疗是一种免疫疗法.巨细胞是一个巨细胞.

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