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使用低强度脉冲超声波重复打开血脑屏障可以缓解粉样蛋白病理

Michael Canney¹, Guillaume Bouchoux¹, Alexandre Carpentier²

¹Carthera, Lyon, France.

Ultrasound in medicine & biology

|November 19, 2025

概括

超声波和微气泡可以安全地打开血脑屏障,从而实现治疗. 在阿尔茨海默氏症患者中重复打开.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
药理学药理学是指药理学的学科.

背景情况:

血脑屏障 (BBB) 限制了大分子和治疗药物的输送到大脑.
超声波 (美国) 与微泡 (MB) 结合,提供了一种策略,可以暂时打开BBB以加强药物输送.

研究的目的:

研究重复开放BBB对健康小鼠神经炎症的影响.
在阿尔茨海默病小鼠模型中,评估重复开放BBB对粉样β (Aβ) 病理学的影响.

主要方法:

野生型小鼠通过US/MBs进行单次BBB打开;脑组织分析炎症标志物.
ARTE10阿尔茨海默氏症模型小鼠接受了重复的US/MB介导BBB开放;评估了Aβ病理和免疫反应.
对脑部提取物进行了定量PCR和组织学分析.

主要成果:

单个BBB开口在野生型小鼠中诱导了轻微的炎症反应.
在ARTE10模型中,重复的BBB打开显示了Aβ病理的轻微减少.
在重复打开BBB后,观察到生长因子的轻微增加.

结论:

超声波介导的BBB打开是向大脑提供治疗的安全方法.
重复打开BBB可能为治疗神经退行性疾病 (如阿尔茨海默氏症) 提供协同效应.

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