当前时代肌肉侵入性膀癌的新辅助疗法后膀保存:神话与现实
Emanuele Crupi1, Andrea Necchi2, Ashish M Kamat3
1Department of Genitourinary Medical Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
European urology focus
|November 19, 2025
概括
对于肌肉侵入性膀癌的新辅助疗法后,膀的保存正在成为一种有纪律的方法. 越来越多的证据和生物标志物策略正在推动缓解膀的治疗方法向成功的膀完整治愈方向发展.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 肌肉侵入性膀癌 (MIBC) 治疗传统上涉及激进囊切除术.
- 膀保护策略正在出现,作为囊切除术的替代方案.
- 随着膀保护的新辅助疗法正在对MIBC进行研究.
研究的目的:
- 评估肌肉侵入性膀癌中膀保存的不断变化的范式.
- 突出从经验方法向基于证据的策略的过渡.
- 讨论新辅助疗法和生物标志物在膀节约治疗中的作用.
主要方法:
- 对不断增长的关于膀保护的前性数据的审查.
- 对共识标准化努力的分析.
- 在治疗规划中整合基于生物标志物的策略.
主要成果:
- 膀保护正在从一个研究型转向一个成熟的证据范式.
- 未来的数据和标准化正在支持节约膀的方法.
- 生物标志物驱动的策略正在提高这些治疗的精度.
结论:
- 在MIBC的新辅助疗法之后,膀的保存是一种有希望的,证据成熟的策略.
- 在等待随机验证之前,当前的数据支持对膀节约采取有纪律的方法.
- 目标是实现肌肉侵入性膀癌患者的膀完整治愈.
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