快速马成像与范围探测:实验性比较用于质子疗法的两个范围验证方法
Stefanie Bertschi1, Giuliano Perotti Bernardini2, Jonathan Berthold1,3,4
1OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine, Dresden, Germany.
Medical physics
|November 19, 2025
概括
快速马成像 (PGI) 和射程探测 (RP) 是在线自适应性质子疗法 (OAPT) 的有效安全网. 这两种方法都能检测解剖变化和设置错误,RP为范围偏差提供更高的精度.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 图像指导 图像指导
背景情况:
- 在线自适应性质子疗法 (OAPT) 需要强大的验证方法,因为传统的质量保证不适用.
- 快速马成像 (PGI) 和范围探测 (RP) 是在OAPT中在线治疗验证和体内范围评估的有希望的技术.
- 这些方法作为关键的安全网,检测偏差而不增加患者剂量或治疗时间.
研究的目的:
- 为了比较快速玛成像 (PGI) 和距离探测 (RP) 在检测解剖变化 (AC) 和设置错误 (SE) 的性能.
- 为了在一个单一的实验设置中评估这些互补的治疗验证方法,使用人类形状的头部幻影.
主要方法:
- 同时设置PGI (幻象下) 和RP (远距离幻象) 在水平门架角度.
- 用笔光束扫描计划和低剂量RP计划对脑目标进行辐射.
- 用水等价材料板模仿AC,用沙发轮换模仿SE,然后对每个配置进行10次重复.
主要成果:
- PGI和RP都检测到在临床光束路径内由AC引起的范围偏差;RP测量比PGI (≤0.8毫米) 更精确 (≤0.3毫米).
- RP独特地检测到超出目标的无关AC,而两种系统都以不同的精度检测到SE.
- 对于特定的沙发移动 (左侧,上游) 和识别的上游移动,PGI的精度更高,而对于SE检测,RP的整体精度更高.
结论:
- PGI和RP有效地检测到与处理领域相关的AC,RP显示出更高的精度.
- 两种系统都检测到SE,尽管不确定性更大;对于大多数SE,RP更准确.
- 保护地理标志和RP的兼容性和独特优势凸显了它们在OAPT中作为安全网的重要作用.
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