弗雷明汉姆肥胖症指数与阻塞性睡眠呼吸暂停之间的关联:一个基于人口的研究
Fa-Dan Tang1, Jing-Ying Ma1, Hai-Lun Xia1
1Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310007, China.
European journal of medical research
|November 20, 2025
概括
脂肪肝指数 (FSI) 与阻塞性睡眠呼吸暂停 (OSA) 的更高风险有关. 这种关联是非线性的,腰与身高的比率 (WHtR) 部分介导了这种关系.
科学领域:
- 代谢和睡眠医学 代谢和睡眠医学
- 公共卫生研究 公共卫生研究
背景情况:
- 非酒精性脂肪肝疾病 (NAFLD) 和阻塞性睡眠呼吸暂停 (OSA) 显示出强烈的相关性.
- 脂肪肝指数 (FSI) 作为OSA风险指标的作用需要进一步研究.
- 目前尚不完全了解FSI-OSA关系背后的机制.
研究的目的:
- 调查脂肪肝指数 (FSI) 和阻塞性睡眠呼吸暂停 (OSA) 之间的相关性.
- 探索FSI-OSA关系中的潜在调解因素,例如腰与身高的比 (WHtR).
- 分析关联的性质,包括非线性和值效应.
主要方法:
- 从NHANES数据库 (2005-2008,2015-2020) 中分析了46,028名参与者.
- 使用了加权多变量逻辑回归,受限立方线 (RCS) 分析和值效应分析.
- 进行了调解分析,以评估WHtR的作用.
主要成果:
- 在FSI和OSA风险之间发现了显著的正相关性 (OR=1.36).
- RCS和值分析显示,FSI和OSA之间存在非线性关联,FSI值较低时风险增加较大.
- 腰与身高的比率 (WHtR) 部分介于FSI-OSA协会的24.5%.
结论:
- 这项研究证实了FSI和OSA之间的正面,非线性相关性.
- 增加的FSI与增加的OSA风险有关.
- 在这种关系中,WHtR扮演着部分调解角色.
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