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在体内CAR细胞疗法:从长椅到床边

Jia Xu^1,2,3, Zhaozhao Chen^1,2,3, Liman Su^1,2,3

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.

Journal of hematology & oncology

|November 20, 2025

概括

活体CAR-T疗法通过直接在体内重新编程T细胞,为传统CAR-T疗法提供了更有效和更经济的替代方案. 这种方法旨在使先进的细胞疗法更容易获得,并为患有血液癌症的患者准备好使用.

科学领域:

免疫治疗是一种免疫疗法.
细胞疗法细胞疗法
在瘤学瘤学.

背景情况:

化学抗原受体T细胞 (CAR-T) 疗法对血液性恶性瘤有效.
目前的自主性ex vivoCAR-T制造是复杂的,昂贵的和耗时的.
这限制了患者获得这种救命治疗的机会.

研究的目的:

审查体内CAR-T细胞疗法的最新进展.
探索从实验室研究向临床应用的过渡.
确定改善体内CAR-T的临床翻译的策略.

主要方法:

关于体内CAR-T疗法的当前科学文献的综述.
分析临床前和临床研究进展情况.
综合发现从长椅到床边.

主要成果:

在体内CAR-T疗法直接重新编程内源性T细胞 in situ.
这种方法绕过了对化和ex vivo细胞制造的需求.
它提出了一个更有效,更经济,更容易获得的治疗模式.

结论:

在体内CAR-T疗法代表了细胞治疗中的显著范式转变.
这种方法使CAR-T走向了"准备好使用"的治疗产品.
进一步的研究对于推进临床翻译和患者可访问性至关重要.

关键词:

腺相关病毒的病毒.基因输送基因输送基因输送在体内进行CAR细胞疗法.隐形病毒载体隐形病毒载体脂质纳米颗粒的使用方法核酸有效载荷的核酸有效载荷聚合物纳米粒子聚合物纳米粒子

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