血清NfL与被诊断为糖尿病的老年人认知功能之间的关联:NHANES的横截面研究
Li Li1, Chengbo Li1, Li Zhu2
1Department of Neurology, Affiliated Hospital of Chengde Medical College, Chengde, China.
Medicine
|November 20, 2025
概括
较高的血清神经丝光链 (NfL) 水平,这是神经元损伤的标志物,与糖尿病患者的认知能力下降有关. 这表明NfL可能表明糖尿病认知障碍风险增加.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 生物标志物研究 生物标志物研究
背景情况:
- 神经纤维光链 (NfL) 是神经元损伤的已知生物标志物.
- 以前的研究将NfL与神经退行性疾病联系起来,但其在糖尿病人群中对认知功能的作用尚不清楚.
- 糖尿病是认知障碍的一个已知的危险因素.
研究的目的:
- 调查血清NfL水平与糖尿病患者认知表现之间的关联.
- 为了确定NfL升高是否是糖尿病队列认知衰退的预测因素.
主要方法:
- 从2013-2014年国家健康和营养检查调查中对179名糖尿病参与者的横截面分析.
- 使用数字符号替换测试评估认知功能,将参与者分为正常功能和认知衰退组.
- 权重后勤回归模型用于分析血清NfL与认知功能之间的关系,调整混因子.
主要成果:
- 在认知功能下降组 (38.63 pg/mL) 的血清NfL水平明显高于正常认知功能组 (25.84 pg/mL;P=.004).
- 在多个因素调整后,血清NfL每单位增加都与认知障碍的几率增加有关 (OR1.04,95%CI:1.010-1.071,P=.031).
- 在糖尿病患者中,NfL度与认知障碍风险之间发现了线性关联.
结论:
- 血清NfL水平升高与糖尿病患者的认知障碍有关.
- 血清NfL可以作为一种潜在的生物标志物,用于识别患有认知衰退风险较高的糖尿病患者.
- 需要进一步的研究来阐明NfL,糖尿病和认知障碍之间的因果机制.
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