双向门德尔随机化分析显示,Helicobacter pylori感染和骨质疏松症风险之间没有因果关系
ZhiXiang Chen1,2, Xiao Yang1,2, YaoWu Chen1,2
1First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha City, Hunan Province, China.
Medicine
|November 20, 2025
概括
这项研究没有发现任何证据表明,Helicobacter pylori (H pylori) 感染会导致骨质疏松症 (OP). 双向的门德尔随机化分析证实H pylori和OP风险之间没有因果关系.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 骨科和骨代谢 骨科和骨代谢
背景情况:
- 杆菌 (H pylori) 感染在全球范围内很常见.
- 骨质疏松症 (OP) 是一个重要的公共卫生问题,其特点是骨质量低和微型结构恶化.
- 在H pylori感染和OP之间的潜在因果关系仍然存在争议.
研究的目的:
- 为了研究H pylori感染和骨质疏松症之间的潜在因果关系.
- 使用双向的双样本门德尔随机化 (MR) 分析来进行可靠的因果推断.
主要方法:
- 使用全基因组关联研究 (GWAS) 数据对两个样本进行门德尔随机化 (MR) 分析.
- 使用多种分析方法,包括反变量加权 (IVW),加权中位数,简单模式和MR-Egger回归.
- 通过使用MR-Egger拦截,MR-PRESSO,Cochran Q测试和留出一个漏洞验证进行了灵敏度分析,以确保可靠性.
主要成果:
- 通过IVW方法显示,抗H pyloriIgG血清阳性和OP之间没有因果关系 (OR:1.03;95%CI:0.90-1.18;P=0.69).
- 没有发现与H pylori真空化细胞毒素A (VacA) 抗体水平 (OR: 1.00; 95% CI: 1.00-1.00; P=0.28) 或H pylori细胞毒素相关基因A蛋白 (CagA) 抗体水平 (OR: 0.95; 95% CI: 0.86-1.05; P=0.31) 的因果关系.
- 双向MR分析始终没有显示H pylori感染和OP之间的因果关系,在敏感性分析中没有发现MR假设的违反.
结论:
- 这项研究没有提供证据支持H pylori感染与患骨质疏松症的风险之间存在因果关系.
- 在多种MR方法和强大的灵敏度分析中,研究结果一致.
- 这些结果有助于解决有关H pylori在骨质疏松病变发生过程中的作用的争议.
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