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中性粒细胞外陷和类风湿性关节炎之间的因果关系:一个双样本双向的门德尔随机化研究

Junwei Luo¹, Xinlong Li, Xi Wang

¹Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

|November 20, 2025

概括

类风湿性关节炎 (RA) 可能因果影响中性粒细胞数量,而不是中性粒细胞外细胞陷. 虽然最初的发现表明中性粒细胞数和RA之间存在联系,但进一步的分析表明,RA影响中性粒细胞数和炎症标志物,而不是相反.

科学领域:

免疫学免疫学免疫学
遗传学遗传学是一个
类风湿病学类风湿病学

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特征是关节炎症.
中性细胞外细胞陷 (NETs) 与自身免疫性疾病有关,但它们在RA中的因果作用尚不清楚.
了解NET和RA之间的双向关系对于开发向疗法至关重要.

研究的目的:

研究中性粒细胞外细胞陷 (NETs) 和类风湿性关节炎 (RA) 之间的潜在因果关系.
检查RA对中性粒细胞数和相关炎症标志物的因果作用.
探索中性粒细胞数量对RA发展的因果关系.

主要方法:

进行了两样双向门德尔随机化 (MR) 分析.
主要分析采用逆方差加权 (IVW) 方法,敏感性分析使用加权中位数,加权模式和MR-Egger回归.
进行了异质性 (Cochran's Q),性 (MR-Egger回归) 和异常值 (MR-PRESSO) 的测试,并进行了离开一个的分析.

主要成果:

双向MR分析表明,RA因果影响中性粒细胞数量,瘤缩因子-α,IL-5,IL-13和髓氧化酶.
在中性粒细胞外细胞陷 (NETs) 和RA之间没有发现显著的因果关系.
虽然初步分析表明中性粒细胞数量和RA之间存在联系,但考虑到异质性和异常值后,这种联系得到了减弱,尽管一些方法仍然暗示着潜在的关系.

结论:

类风湿性关节炎 (RA) 对中性粒细胞数和特定的炎症标志物有因果作用,而不是相反.
中性细胞外细胞陷 (NETs) 似乎没有在RA的发病过程中起因果作用.
需要进一步调查以澄清中性粒细胞动态和RA之间的复杂相互作用,特别是考虑到剩余的关联暗示.

关键词:

门德尔的随机化有关因果关系的因果关系它们包括interleukins.中性粒细胞外细胞陷类风湿性关节炎类风湿性关节炎

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