用于癌症诊断的基于水凝的设备:对材料和生物标志物的系统审查
Rosalina Intan Saputri1, Adelaide Mensah1, Aoife M Rodgers2
1School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, UK.
Future science OA
|November 20, 2025
概括
水凝显示出作为诊断设备的承诺,用于检测液体活检中的癌症生物标志物. 需要进一步的研究来验证它们在临床环境中用于个性化癌症治疗的使用.
科学领域:
- 生物材料科学 生物材料科学
- 在瘤学瘤学.
- 分子诊断学 分子诊断
背景情况:
- 个性化癌症治疗依赖于分子分析来定制治疗.
- 水凝正在成为液体活检中癌症生物标志物检测的工具.
研究的目的:
- 系统地审查和评估水凝作为癌症生物标志物检测诊断设备的性能.
- 识别常用的水凝聚合物,癌症类型和检测到的生物标志物.
主要方法:
- 按照PRISMA的指导方针,对五个主要数据库 (PubMed,Scopus,Embase,MEDLINE,EBSCO) 进行了系统的文献搜索.
- 研究进行了选,选择和质量评估,提取了有关水凝特性,癌症类型,样本细节和检测方法的相关数据.
主要成果:
- 该审查分析了33项研究,确定了烯胺,PEG,DNA和酸盐作为经常使用的水凝聚合物.
- 乳腺癌,肝癌和宫癌是最受研究的,循环瘤细胞 (CTC) 和蛋白质标记物是主要检测到的生物标记物.
结论:
- 水凝代表了早期癌症生物标志物检测的有希望的平台.
- 优化和验证对于将水凝应用转化为用于个性化癌症护理的临床诊断设备至关重要.
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