ZOVER 2.0:一种基于病毒的平台,用于动物性和载体传播的病毒
1NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, China.
Nucleic acids research
|November 20, 2025
概括
通过分析野生动物的元基因组数据,ZOVER 2.0数据库增强了病毒监测. 它扩大了对蝙蝠,动物,蚊子和的病毒多样性的理解,以促进公共卫生.
科学领域:
- 病毒学 病毒学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 新兴的动物性和媒介性病毒对全球健康构成威胁.
- 有效的病毒群监测需要了解野生动物储库和载体中的病毒和宿主多样性.
研究的目的:
- 升级ZOVER数据库以扩展的元基因组数据进行全面的病毒组概况.
- 为病毒发现,生态解释和物种间传播的监测提供一个标准化的平台.
主要方法:
- 在12年内从72个项目中整合了5883个策划的元基因组下一代测序库.
- 使用标准化分析管道进行分类注释和病毒丰度估计.
- 规范化测序读取在各种数据集中进行一致的分析.
主要成果:
- 通过将读数分配给蝙蝠,动物,蚊子和的110个已知的病毒家族来扩大病毒组多样性.
- 能够对跨种类,区域和时间的病毒组合进行可视化和比较分析.
- 综合基因组和元基因组知识,用于强大的病毒发现.
结论:
- ZOVER 2.0为监测新出现的传染病提供了一个强大的资源.
- 通过了解病毒生态和传播风险,促进以健康为导向的监测.
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